Januka Budhathoki Uprety
Works (29)
Updated: April 4th, 2024 15:30
2023 journal article
Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media
ACS Applied Nano Materials, 6(17), 15530–15539.
author keywords: disinfectants; COVID-19 pandemic; quaternaryammonium compounds (QACs); single-walled carbon nanotubes(SWCNTs); nanosensor; human health; near-infraredprobe
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: October 10, 2023
2023 conference paper
Development of Optical Nanosensors for pH Measurements in Model Biofluids
[Poster]. ECS Meeting Abstracts, 243(9), 1166–1166.
Event: ECS Meeting
TL;DR:
It is reported that SWCNT-based sensors can reliably detect pH changes in a model biofluid - artificial sweat and exhibited significant responses within biologically relevant pH ranges within minutes through changes in the nIR fluorescence.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 30, 2023
2023 article
Greener Dyeing
Budhathoki-Uprety, J. (2023, March). CHEMISTRY & INDUSTRY, Vol. 87, pp. 22–25.
Sources: Web Of Science, NC State University Libraries
Added: May 15, 2023
2023 conference paper
Nanoscale Probes for Optical Detection of Emerging Contaminants and Biological Indicators
ECS Meeting Abstracts, MA2023-01(9), 1130–1130.
TL;DR:
This talk will be focused on the development and applications of carbon nanotube-based sensors for optical detection of emerging contaminants and biological indicators including pH, a measure of acidity and alkalinity of a sample.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 30, 2023
2023 conference paper
Optical Nanosensors for the Detection of Quaternary Ammonium Compounds
ECS Meeting Abstracts, MA2023-01(9), 1132–1132.
TL;DR:
A carbon nanotube-based optical sensor for the detection of QACs in complex solution is developed and could provide a basis for engineering an optical detection technology to gain insight on the long-term effects ofQACs to human health.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: November 30, 2023
2022 review
Increased Use of Disinfectants During the COVID-19 Pandemic and Its Potential Impacts on Health and Safety
[Review of ]. ACS CHEMICAL HEALTH & SAFETY, 29(1), 27–38.
author keywords: disinfectants; COVID-19; antiviral; facemask; indoor air; sanitizers; bleach; quaternary ammonium compounds (QACs)
TL;DR:
A well-rounded understanding of the most common disinfectants is provided and modes of action of those disinfectants, their interactions with aquatic and terrestrial environments, the exposure to humans, and potential impacts to human health and safety are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 7, 2022
2022 journal article
Optical detection of pH changes in artificial sweat using near-infrared fluorescent nanomaterials
Sensors & Diagnostics, 1(6), 1189–1197.
pubs.rsc.org (publisher PDF)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: October 11, 2022
2022 article
Polycarbodiimide for Textile Dye Removal from Contaminated Water
Lord, M. D., Neve, G., Keating, M., & Budhathoki-Uprety, J. (2022, July 22). ACS APPLIED POLYMER MATERIALS, Vol. 7.
author keywords: textile dyes; environmental pollution; clean water; sustainability; polycarbodiimide; topological polar surface area (TPSA); molecular transport
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 8, 2022
2021 conference paper
Carbon Nanotubes Cloaked in Synthetic Polymers: Aqueous Dispersion, Characterization, and Applications
ECS Meeting Abstracts, MA2021-01(10), 513–513.
Sources: ORCID, Crossref, NC State University Libraries
Added: August 20, 2022
2021 journal article
Harnessing nanotechnology to expand the toolbox of chemical biology
NATURE CHEMICAL BIOLOGY, 17(2), 129–137.
MeSH headings : Animals; Biocompatible Materials; Drug Carriers / chemistry; Drug Delivery Systems; Enzymes / chemistry; Humans; Molecular Biology / methods; Molecular Biology / trends; Molecular Imaging / methods; Nanoparticles; Nanotechnology / trends
TL;DR:
This Perspective introduces chemical biologists to potentially useful nanotechnologies, aims to inspire Nanotechnologists to address questions relevant to chemical biology, and identifies possible opportunities for the two fields to collaborate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 25, 2021
2021 journal article
Non-Covalent Coatings on Carbon Nanotubes Mediate Photosensitizer Interactions
ACS APPLIED MATERIALS & INTERFACES, 13(43), 51343–51350.
author keywords: donor-acceptor; binding; metrology; interface; hybrid; dyes; substrate
TL;DR:
It is demonstrated that the dye binding location is an important factor in this process: the coated-acceptor chromatic responses are used and it is found that dye binding is affected by the coating layer.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 23, 2021
2021 journal article
Single-Chirality Near-Infrared Carbon Nanotube Sub-Cellular Imaging and FRET Probes
NANO LETTERS, 21(15), 6441–6448.
author keywords: Multiplexing; biosensor; dual-color imaging; near-infrared sensor; energy transfer
MeSH headings : Diagnostic Imaging; Fluorescence Resonance Energy Transfer; Humans; Nanotubes, Carbon; Polymers; Surface-Active Agents
TL;DR:
This work developed single-chirality subcellular SWCNT imaging probes and investigated their internanotube FRET capabilities in live cells, and portends the use of single- chirality carbon nanotube optical probes for applications in biomedical research.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 30, 2021
2020 journal article
Carbon Nanotube and Organic Color Center Solvatochromism in Biomedicine
ECS Meeting Abstracts, MA2020-02(67), 3409–3409.
Source: ORCID
Added: August 20, 2022
2020 journal article
Glutathione-S-transferase Fusion Protein Nanosensor
NANO LETTERS, 20(10), 7287–7295.
author keywords: Fluorescent sensor; nanocarbon; solvatochromism; affinity tag
MeSH headings : Chromatography, Affinity; Glutathione; Glutathione Transferase / genetics; Proteins
TL;DR:
This work comprises the first label-free optical sensor for GST and has implications for the assessment of protein expression in situ, including in imaging and industrial bioreactor settings.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 19, 2020
2020 conference paper
Polymer Functionalized Nanocarbons for Biomedical Applications
ECS Meeting Abstracts, MA2020-02(67), 3411–3411.
Sources: ORCID, Crossref, NC State University Libraries
Added: August 20, 2022
2019 journal article
Synthetic molecular recognition nanosensor paint for microalbuminuria
NATURE COMMUNICATIONS, 10.
MeSH headings : Albumins / chemistry; Albumins / isolation & purification; Albuminuria / diagnosis; Albuminuria / urine; Biomarkers / blood; Biomarkers / urine; Biosensing Techniques / methods; Blood Proteins / analysis; Fatty Acids; Humans; Immobilization; Nanostructures / chemistry; Paint; Spectrometry, Fluorescence; Urine / chemistry
TL;DR:
A nanosensor paint was developed using a polymer to mimic fatty acid binding to albumin, transduced by carbon nanotube fluorescence that enables the detection of microalbuminuria in patient samples and comprises a rapid point-of-care sensor robust enough to be deployed in resource-limited settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 26, 2019
2018 journal article
Quantitative self-assembly prediction yields targeted nanomedicines
Nature Materials.
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Carriers / pharmacokinetics; Endocytosis; Indoles / chemistry; Mice; Nanomedicine / methods; Nanoparticles / chemistry; Particle Size; Tissue Distribution
TL;DR:
A targeted drug delivery system that is accurately and quantitatively predicted to self-assemble into nanoparticles based on the molecular structures of precursor molecules, which are the drugs themselves.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 27, 2019
2018 journal article
The secondary structures of PEG-functionalized random copolymers derived from (R)- and (S)- families of alkyne polycarbodiimides
Polymer Chemistry.
Source: ORCID
Added: August 27, 2019
2017 journal article
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux
ACS Nano.
author keywords: single-walled carbon nanotubes; single-cell sensing live-cell imaging; near-infrared fluorescence; hyperspectral microscopy
MeSH headings : Atherosclerosis / blood; Atherosclerosis / pathology; DNA, Single-Stranded / blood; DNA, Single-Stranded / chemistry; Endosomes / chemistry; Humans; Lipids / chemistry; Luminescent Measurements; Lysosomes / chemistry; Lysosomes / metabolism; Macrophages / chemistry; Macrophages / metabolism; Monocytes / chemistry; Monocytes / metabolism; Nanotubes, Carbon / chemistry; Niemann-Pick Disease, Type C; Optics and Photonics / instrumentation; Single-Cell Analysis / methods; Transport Vesicles / chemistry; Transport Vesicles / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 27, 2019
2017 journal article
A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway
ACS Nano.
author keywords: helical polymer; hyperspectral imaging; cervical cancer; near-infrared sensor; biosensor; polycation; nuclear pore complex
MeSH headings : Active Transport, Cell Nucleus; Cell Nucleus / metabolism; HeLa Cells; Humans; Luminescent Agents / chemistry; Luminescent Agents / metabolism; Microscopy, Fluorescence; Molecular Structure; Nanotubes, Carbon / analysis; Nanotubes, Carbon / chemistry; Optical Imaging; Polymers / chemistry; Tumor Cells, Cultured
TL;DR:
A carbon nanotube based hybrid material is developed that elucidate a distinct mechanism of nuclear translocation of a nanomaterial in cultured cells and provides a reporter for the study of nucleus-related pathologies.
(via Semantic Scholar)
Source: ORCID
Added: August 27, 2019
2017 article
A carbon nanotube optical reporter maps endolysosomal lipid flux
Jena, P. V., Roxbury, D., Galassi, T. V., Akkari, L., Horoszko, C. P., Iaea, D. B., … Heller, D. A. (2017, May 6). (Vol. 5). Vol. 5.
TL;DR:
An optical reporter, composed of a photoluminescent carbon nanotubes of a single chirality, which responds to lipid accumulation via modulation of the nanotube’s optical bandgap, which confers new capabilities for drug development processes and the investigation of lipid-linked diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: November 19, 2020
2017 journal article
Control of Carbon Nanotube Solvatochromic Response to Chemotherapeutic Agents
ACS Applied Materials & Interfaces.
author keywords: nanosensor; fluorescence; photoluminescence; cis-diammineplatinum(II) dichloride; antineoplastic; mustard agent
MeSH headings : Adsorption; Antineoplastic Agents; DNA, Single-Stranded; Nanotubes, Carbon
TL;DR:
A new approach to control the direction and magnitude of solvatochromic responses of carbon nanotubes is described and it is found that the alkylation of DNA on the nanotube surface can result in small changes in DNA conformation that allow the adsorption of amphiphiles to produce large differences in response to different drugs.
(via Semantic Scholar)
Source: ORCID
Added: August 27, 2019
2017 journal article
Polymer cloaking modulates the carbon nanotube protein corona and delivery into cancer cells
J. Mater. Chem. B.
TL;DR:
This work modulated functional moieties on a helical polycarbodiimide polymer backbone that non-covalently suspended the nanotubes in aqueous media and obtained nanotube complexes that present net surface charges of opposite polarity at physiological pH.
(via Semantic Scholar)
Source: ORCID
Added: August 27, 2019
2014 journal article
Helical Polycarbodiimide Cloaking of Carbon Nanotubes Enables Inter-Nanotube Exciton Energy Transfer Modulation
Journal of the American Chemical Society.
MeSH headings : Carbodiimides / chemistry; Energy Transfer; Nanotubes, Carbon
TL;DR:
A small library of polycarbodiimides was synthesized to noncovalently encapsulate SWCNTs with a diverse set of functional coatings, enabling their suspension in aqueous solution and facilitating the first instance of controllable and reversible internanotube exciton energy transfer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: August 27, 2019
2012 journal article
Determining the Regioregularity in Alkyne Polycarbodiimides and Their Orthogonal Modification of Side Chains To Yield Perfectly Alternating Functional Polymers
MACROMOLECULES, 45(20), 8155–8165.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities
ACS MACRO LETTERS, 1(3), 370–374.
TL;DR:
These polycarbodiimide-guanidinium-triazole conjugates offered moderate to significant antibacterial activity and rapid interaction with red blood cells causing blood precipitation without significant hemolysis in case of Poly-2(b-e).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Stable-Isotope Labeled Hydrophobic Hydrazide Reagents for the Relative Quantification of N-Linked Glycans by Electrospray Ionization Mass Spectrometry
ANALYTICAL CHEMISTRY, 83(17), 6738–6745.
MeSH headings : Carbon Isotopes / chemistry; Glycopeptides / analysis; Glycosylation; Hydrazones / chemistry; Hydrophobic and Hydrophilic Interactions; Isotope Labeling; Polysaccharides / analysis; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
It is shown that these reagents are capable of quantifying changes in glycosylation in simple mixtures, and the analytical variability of the reagents in pooled plasma samples is shown to be less than ±30%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Synthesis of Alkyne-Functionalized Helical Polycarbodiimides and their Ligation to Small Molecules using 'Click' and Sonogashira Reactions
MACROMOLECULES, 44(15), 5947–5954.
TL;DR:
The synthesis of the first alkyne substituted polycarbodiimides,Poly-1, Poly-2, and Poly-3 is reported and the quantitative coupling of functional azides to theAlkyne repeat units of these polymers, as evidenced by IR and 1H NMR and 13C NMR spectra.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Synthesis of a pyridine substituted polycarbodiimide and its use as a solid support for chemical reagents
POLYMER, 51(10), 2140–2146.
author keywords: Polycarbodiimide; Supported pyridine-borane reagent; Helical polymer
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
Employment
Updated: June 7th, 2019 08:01
North Carolina State University Raleigh, NC, US
Assistant Professor
Textile Engineering, Chemistry and Science
Education
Updated: August 27th, 2019 10:04
2012 - 2018
Memorial Sloan Kettering Cancer Center New York, NY, US
Postdoctoral Fellow
Molecular Pharmacology Program
2008 - 2012
North Carolina State University Raleigh, NC, US
Ph.D. in Chemistry
Department of Chemistry
2007 - 2008
Western Carolina University Cullowhee, North Carolina, US
M.S. in Chemistry
Department of Chemistry and Physics
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