Finding a Method of Synthesis
Finding a preparation or synthesis method is a central task in organic chemistry. For simple, common chemicals, numerous synthesis methods have already been discovered. You wouldn’t want to spend costly time in the lab developing a new method until you knew what was already out there. The good news is that there are some really great tools for this task.
The sources in this section cite scholarly journal articles about methods of preparation (also known as synthesis) of your compound. You need to locate the article itself to learn about the method of synthesis. The NCSU Libraries will have most of the journal articles you need to refer to. The steps below outline the process of finding these journals.
Using Reaxys to locate a synthesis reference
Reaxys is a recommended database for finding synthesis references.
First, search for your compound in the Ask Reaxys box. Use the CAS Registry Number for searching if you have it.
In the search results, you will see a column of data related to preparation methods. Reaxys will report the number of preparations found out of the total number of reactions.
Click on the number of preparations to obtain a list of reactions in which your chemical was a product (in other words, it was synthesized using the reaction). For each reaction, Reaxys provides a reaction diagram and references to the journal articles in which the reactions are described.
Click on the "Full Text" link to access the article. If you are unable to access the article using this link (e.g., you get a login screen or error message), note the citation (author, journal title, year, volume, pages) and search the library's journal list for the issue you need. Feel free to ask a librarian for help locating the article.
Tip: Older methods might be easier to work with.
Tip: You may need to look through a few different articles before you find one that is clear.
Other possible sources
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