College of Veterinary Medicine


Dr. Jim Riviere & Dr. Nancy A. Monteiro-Riviere, professors at the College of Veterinary Medicine at NC State, received the patent described below. To find additional information on this patent, search the U.S. Patent Office Database at:

Photo of Jim Riviere.
Dr. Jim Riviere

Dr. Nancy A. Monteiro-Riviere

Iontophoretic Electrode
U.S. Patent Number 5,540,654
  Description of Patent #5,540,654 entitled, "Iontophoretic Electrode." Figure of Voltage Source accompanying Patent # 5,540,654.
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Dr. Jim Riviere works to develop quantitative mechanistic models of chemical absorption across skin; applied to transdermal drug delivery, percutaneous absorption of topically applied chemical mixtures and pesticides and delivery of peptides by iontophoresis. His research stresses developing biologically relevant in vitro models (e.g. perfused skin flaps) and making quantitative in vivo human predictions. He studies the mechanism of chemical penetration, biotransformation and vascular uptake. He is also interested in pharmacokinetics of targeted drug delivery and drug residues in food animals.
Dr. Nancy A. Monteiro-Riviere focuses her research on the toxicity of environmental and novelpharmaceutical compounds. She assesses dermatotoxicity and absorption in both in vivo and in vitro model systems. She uses pigskin as a model because of its anatomical, physiological and biochemical similarity to human skin. These shared attributes are important for assessing the absorption of many compounds. Monteiro-Riviere studies the pathogenesis and mechanism of toxicity of many environmental compounds.