Title page for ETD etd-11302004-115753

Type of Document

Dissertation

Author

Allen, Angela M.,

Author's Email Address

delta1_95@hotmail.com

URN

etd-11302004-115753

Title

THE INTERACTION OF BORONIC ACID BASED SELF?ASSEMBLED MONOLAYERS AS A POTENTIAL GLUCOSE SENSOR

Degree

PhD

Graduate Program

Chemistry

Advisory Committee

Advisor Name	Title
Christopher Gorman	Committee Chair
Charles B. Boss	Committee Member
Edmond F. Bowden	Committee Member
Kenneth W. Hanck	Committee Member

Keywords

biosensors
boronic acid
monolayers

Date of Defense

2004-09-10

Availability

unrestricted

Abstract

Recognition of sugars such as glucose with phenylboronic acid?terminated self assembled monolayers (SAMs) was the basis for the designing
and fabricating a biosensor. Self-assembled monolayers were formed on gold surfaces as shown by infrared spectroscopy. The continuous, repeatable increase of the electrochemical impedance as the concentration of glucose was
increased gave indication of binding. This binding could be attributed to the precedent formation of relatively stable esters between phenylboronic acids and sugars. This impedance change upon binding between glucose and a
phenylboronic acid-terminated SAM showed promise in the development of a glucose biosensor.

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