This series primarily pertains to the origins of the animal rights movement and basic information on the movement itself. It also has a plethora of documents relating to general animal care. The series consists of flyers, pamphlets, advertisements, booklets, posters, and reports from a variety of local, national, and international animal rights groups. The correspondence mainly stems from animal rights groups, but some of the letters are from the Giduz's or other individuals involved in the movement. There are also newspaper, journal, and magazine articles from around the country including , , , the Raleigh , the , the , and the .

This series documents animal research in general and alternative methods of research. There are ephemeral materials, including papers, bulk mail, pamphlets, flyers, advertisements, newsletters, journal, newspaper, and magazine articles, and other forms of promotional materials produced by different animal rights groups. The folder Animal Research contains two papers: the Animal Rights Protection Society of Orange County's paper entitled ; and Gul Agha's paper entitled, . The folder Alternatives to Animal Research has some abstracts and a bibliography as well. The folder UNC, Crisp List contains two annual reports from the Animal and Plant Health Inspection and computer printouts on different types to testing used on different species of animals.

This series, the largest in the collection, has documents pertaining to the various local, national, and international animal rights groups. Many of the folders contain correspondence, newspaper and magazine articles, pamphlets, flyers, and handouts that promote either the organization or the various animal rights issues they are concerned with. Much of the correspondence includes membership letters or is between the Giduz's and various officials of animal rights groups, such as Neal Barnard (president of PCRM ), Nancy Rich (N.C. Network for Animals), and Ingrid Newkirk (PETA). Other significant materials include: a paper written by Tom and Betsy Giduz entitled created in conjunction with the Physicians Committee for Responsible Medicine; documents on primate research, primarily the Silver Spring Monkeys, associated with the People for the Ethical Treatment of Animals (PETA) organization; photographs and slides from PETA's unauthorized visit to the University of North Carolina at Chapel Hill Animal Holding Facility in December 1988; and court documents relating to the SETA v. Dr. William D. Huffines, who at the time of the case was Chairman of the Institutional Animal Care and Use Committee of the University of North Carolina at Chapel Hill. This series is arranged alphabetically.

This series contains documents addressing the various issues that concern many animal rights activists. Many of the items, like newspaper, journal, magazine articles, pamphlets, and flyers, discuss the different sides to each issue, and in many cases offer solutions to a particular issue. Much of the correspondence was generated by either the Giduz' or other individuals affiliated with the various animal rights groups. The Cosmetic Testing folder contains some photographs of animal experiments. The folder Dog and Cock Fighting contains a couple of petitions to end the practice. In the Fur and Anti-Trap folder, there are several stickers and bumper sticker that promote a ban on wearing fur. The issues are arranged alphabetically.

This series offers documents that discuss the various forms of protest, dissection in biology classes, and human-animal interactions. It contains a range of teaching materials as well. Most of the documents come in the form of pamphlets, booklets, newspaper and magazine articles, handouts, flyers, and worksheets. In the folder Humane Bibliography, there are two bibliographies on animal abuse, animal rights, and animal welfare. This series is arranged alphabetically.

This series contains research on legal matters pertaining to animals and animal rights protection. The folder Ordinances contains various North Carolina counties' and Jefferson County, Kentucky animal ordinances. The series is arranged alphabetically.

This series includes research on how religion has played a role in the animal rights movement. The documents, like newsletters, pamphlet, magazine articles, and correspondence, in this series were primarily generated by the Unitarian Universalists for Ethical Treatment of Animals.

This series contains editorials, journal articles, primarily from journals like (NARSAD), (FASEB), (NEJM), and (NCMJ), miscellaneous newsletters from various local animal rights groups, and catalogs that either promote merchandise from a particular organization or products that were not tested on animals. Many of the articles in the folder Editorials are written by Belton P. Mouras (API). The various articles in the folder Medical Journal Articles discuss the authors' position on a topic relating to animal research and its association with medicine. The articles are arranged chronologically by date of publication.