North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics 1981-2011

Creator
North Carolina State University. Center for Chemical Toxicology Research and Pharmacokinetics
Size
40.86 linear feet
Location

For current information on the location of these materials, please consult the Special Collections Research Center Reference Staff.

Call number
UA 145.041

The North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics records contain laboratory and experiment log books of projects and grants related to studies of Isolated Perfused Porcine Skin Flaps (IPPSF). These records also include two pieces of historic equipment used for these experiments: an Osborne computer for the Food Animal Residue Avoidance Databank (FARAD) and a pressure transducer. Materials range in date from 1981 to 2011.

The Center for Chemical Toxicology Research and Pharmacokinetics performs research on the structure and function of skin focused on transdermal drug delivery, cutaneous toxicology, metabolism and pharmacokinetics employing innovative animal models and other pharmacokinetic research. The Center also helps maintain the USDA-supported Food Animal Residue Avoidance Databank (FARAD), a program established to prevent or mitigate illegal or harmful residues of drugs, pesticides, biotoxins and other chemical agents that may contaminate foods of animal origin.

Biographical/historical note

The Cutaneous Pharmacology and Toxicology Center, located in the College of Veterinary Medicine, was chartered by the UNC Board of Governors on March 10, 1989 to "Perform scientific research on the structure and function of skin focused on transdermal drug delivery, cutaneous toxicology, metabolism and pharmacokinetics employing innovative animal models and other pharmacokinetic research." This extensive research led to the creation, establishment and maintenance of the national USDA-supported Food Animal Residue Avoidance Databank (FARAD) in 1981. FARAD was established to prevent or mitigate illegal or harmful residues of drugs, pesticides, biotoxins and other chemical agents that may contaminate foods of animal origin.The Center was renamed the Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP) by UNC President Molly Broad on December 6, 2001 to officially reflect this dual mission. These two formal missions guide the nature of the research performed by the CCTRP and provide the necessary research base to support a rigorous graduate and post-graduate training program in comparative pharmacology, general toxicology and nanotechnology designed to produce health scientists for academia, industry and government.

The Center has been awarded numerous pretigious grants from agencies such as the National Institute of Occupational Safety and Health (NIOSH), the Environmental Protection Agency (EPA), the Agency for Toxic Substances and Disease Registry (ATSDR), and the Department of Defense to conduct experiments on porcine (pig) skin flaps, which have proven to apply to human skin as well. Many of these studies have been carried out by Dr. Jim Riviere, the co-founder and co-director of FARAD and the Director of the Center for Chemical Toxicology Research and Pharmacokinetics.

Scope/content

The North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics contain laboratory and experiment log books documenting grants awarded to the Center for studies of Isolated Perfused Porcine Skin Flaps (IPPSF). These records also include two pieces of historic equipment used for these experiments, an Osborne computer for the Food Animal Residue Avoidance Databank (FARAD) and a pressure transducer. Materials range in date from 1981 to 2011.

Physical description

25 cartons, 2 oversize boxes

Arrangement

Materials are arranged by project (that may span several grants). They are mostly chronological.

Use of these materials

The nature of the NCSU Libraries' Special Collections means that copyright or other information about restrictions may be difficult or even impossible to determine despite reasonable efforts. The NCSU Libraries claims only physical ownership of most Special Collections materials.

The materials from our collections are made available for use in research, teaching, and private study, pursuant to U.S. Copyright law. The user must assume full responsibility for any use of the materials, including but not limited to, infringement of copyright and publication rights of reproduced materials. Any materials used for academic research or otherwise should be fully credited with the source.

This collection may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in this collection without the consent of those individuals may have legal ramifications (e.g., a cause of action under common law for invasion of privacy may arise if facts concerning an individual's private life are published that would be deemed highly offensive to a reasonable person) for which North Carolina State University assumes no responsibility.

Preferred Citation

[Identification of item], North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, UA 145.041, Special Collections Research Center, North Carolina State University Libraries, Raleigh, NC

Related material

Source of acquisition

Transferred from the North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics.

Processing information

Processed by: Cathy Dorin-Black, 2013 December; Finding aid written by: Cathy Dorin-Black, 2013 December.

Isolated Perfused Porcine Skin Flap Log Books 1 and 2, Experiment Books: GF4 to GF14 1984-1991 (Accession 2013.0293)

Missing 1,2,3,9,11, and 12

Carton 1
Isolated Perfused Porcine Skin Flap Experiment Books: GF15 to GF30 1991-1997 (Accession 2013.0293)
Carton 2
Isolated Perfused Porcine Skin Flap Experiment Books GF31 to GF50 1997-2001 (Accession 2013.0293)
Carton 3
Isolated Perfused Porcine Skin Flap Experiment Books GF51 to GF70 2001-2007 (Accession 2013.0293)

Missing 67 and 68

Carton 4
Isolated Perfused Porcine Skin Flap Experiment Books GF71 to GF84 2007-2011 (Accession 2013.0293)

Missing 75,76,77, and 84

Carton 5
EIA and PGE Assays 1991-1992 (Accession 2013.0293)
Carton 5
DOD Gulf War Flaps 2001 (Accession 2013.0293)
Carton 5
Isolated Perfused Porcine Skin Flap Timed Sample Documentation: SF125 - SF1201 1986-1991 (Accession 2013.0293)
Carton 6
Isolated Perfused Porcine Skin Flap Timed Sample Documentation: SF1202 - SF2837 1991-2002 (Accession 2013.0293)
Carton 7
Isolated Perfused Porcine Skin Flap Timed Sample Documentation: SF2838 - SF3631 2002-2011 (Accession 2013.0293)
Carton 8
EPA Grant Phenol and p-Nitrophenol Neat Acetone and Ethanol Isolated Perfused Porcine Skin Flap SF1420 to SF1731 1991 Dec. 9-1992 Nov. 6 (Accession 2013.0293)
Carton 9
DOD Grant - HD (Mustard Gas) 1991-1995 (Accession 2013.0293)
Carton 10
Gulf War - HD 2001 (Accession 2013.0293)
Carton 10
DOD Grant - Vascular Volume Study, 14C-Inulin and 125I-BSA 1988, 1992-1993 (Accession 2013.0293)
Carton 11
DOD Grant - 14C-HD (Mustard Gas) Penetration 1993-1994 (Accession 2013.0293)
Carton 11
DOD Grant - C-Methyl Salicylate HD-Simulant Penetration 1999 (Accession 2013.0293)
Carton 11
AFOSR Grant CPFB (Chloropentafluorobenzene) 1996 (Accession 2013.0293)
Carton 11
NIEHS Grant (Nicotinic Acid) 1994 (Accession 2013.0293)
Carton 12
Battelle Grant 1995 (Accession 2013.0293)
Carton 12
Pharmacia-Upjohn Grant (Proprietary Compound) 1998 (Accession 2013.0293)
Carton 12
Ethoxylates Grant IPPSF and PSFT 1998-1999 (Accession 2013.0293)
Carton 12
Navy Grant 2002 (Accession 2013.0293)
Carton 12
NIEHS Grant Mechanistically Defined Chemical Mixtures 1994-1995 (Accession 2013.0293)
Carton 13
ATSDR Grant (Agency for Toxic Substances and Disease Registry) Pentachlorobiphenyl 1998-1999 (Accession 2013.0293)
Carton 13
ATSDR Grant (Agency for Toxic Substances and Disease Registry) Pig Skin Flow Thru, Pentachlorophenol 2001 (Accession 2013.0293)
Carton 13
EPA Grant Pentachlorophenol Isolated Perfused Porcine Skin Flap (PSFT) Porcine Skin Flow-Through Diffusion Cells In vivo Pigs 1995-1996 (Accession 2013.0293)
Carton 14
EPA Grant Tetrachlorobiphenyl Isolated Perfused Porcine Skin Flap, Porcine Skin Flow-Through Diffusion Cells In vivo Pigs 1997-1998 (Accession 2013.0293)
Carton 15
AFOSR Grant Jet Fuels (IPPSF) Isolated Perfused Porcine Skin Flap SF2320 to SF2833 1998 May 7-2002 Feb. 15 (Accession 2013.0293)
Carton 16
AFOSR Grant Jet Fuels (PSFT) Porcine Skin Flow-Through Diffusion Cells 1999-2001 (Accession 2013.0293)
Carton 17
DOD Grant - Gulf War Isolated Perfused Porcine Skin Flap (PSFT) Porcine Skin Flow-Through Diffusion Cells 1991-2001 (Accession 2013.0293)
Carton 18
NIOSH Grant Cutting Fluids (IPPSF) Isolated Perfused Porcine Skin Flap (PSFT) Porcine Skin Flow-Through Diffusion Cells 2000-2004 (Accession 2013.0293)
Carton 19
NIOSH Grant Chemical Mixtures (PSFT) Porcine Skin Flow-Through Diffusion Cells 2002-2003 (Accession 2013.0293)
Carton 20
NIOSH Grant Chemical Mixtures (PSFT) Porcine Skin Flow-Through Diffusion Cells 2002-2003 (Accession 2013.0293)
Carton 21
NIOSH Grant Chemical Mixtures (PSFT) Porcine Skin Flow-Through Diffusion Cells 2002 (Accession 2013.0293)
Carton 22
NIOSH Grant Chemical Mixtures (PSFT) Porcine Skin Flow-Through Diffusion Cells 2009 (Accession 2013.0293)
Carton 23
NIOSH Grant Chemical Mixtures (IPPSF) Isolated Perfused Porcine Skin Flap SF2920 to SF3273 2003 June 18-2007 Jul. 26 (Accession 2013.0293)
Carton 24
NIOSH Grant Chemical Mixtures Isolated Perfused Porcine Skin Flap SF3274 to SF3599 2007 Aug. 1-2010 May 12 (Accession 2013.0293)
Carton 25
FARAD (Food Animal Residue Avoidance Databank) First Computer Osborne Computer, Co. Model# OCC1 1981 (Accession 2013.0293)
Oversize box 26
First Pressure Transducer for the (IPPSF) Isolated Perfused Porcine Skin Flap Chambers 1984 (Accession 2013.0293)
Oversize box 27

Access to the collection

This collection is open for research; access requires at least 48 hours advance notice.

For more information contact us via mail, phone, or our web form.

Mailing address:
Special Collections Research Center
Box 7111
Raleigh, NC, 27695-7111

Phone: (919) 515-2273

Preferred Citation

[Identification of item], North Carolina State University, College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, UA 145.041, Special Collections Research Center, North Carolina State University Libraries, Raleigh, NC

Use of these materials

The nature of the NCSU Libraries' Special Collections means that copyright or other information about restrictions may be difficult or even impossible to determine despite reasonable efforts. The NCSU Libraries claims only physical ownership of most Special Collections materials.

The materials from our collections are made available for use in research, teaching, and private study, pursuant to U.S. Copyright law. The user must assume full responsibility for any use of the materials, including but not limited to, infringement of copyright and publication rights of reproduced materials. Any materials used for academic research or otherwise should be fully credited with the source.

This collection may contain materials with sensitive or confidential information that is protected under federal or state right to privacy laws and regulations. Researchers are advised that the disclosure of certain information pertaining to identifiable living individuals represented in this collection without the consent of those individuals may have legal ramifications (e.g., a cause of action under common law for invasion of privacy may arise if facts concerning an individual's private life are published that would be deemed highly offensive to a reasonable person) for which North Carolina State University assumes no responsibility.