Bite-sized Research Series: CRISPR technology in functional food and human health
CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats) systems are bacterial native systems that provide adaptive immunity against invasive genetic elements, such as phages and plasmids. Since the discovery of CRISPR-Cas systems and its possible applications for genome editing, this technology has been proposed as the new revolution in genetic engineering. This technology is precise, cheaper and easier to achieve than other methodologies for genome editing, and offers enormous possibilities in every organism, from bacteria to human genetics.
The CRISPR laboratory at North Carolina State University (https://crispr.cals.ncsu.edu/) supervised by Dr. Rodolphe Barrangou is one of the most experienced and productive laboratory within CRISPR technology, and the unique one using this technology in functional foods to improve human health. Dr. Hidalgo's current research project is to pursue CRISPR technology to improve human health based on (1) CRISPR food microbiology applications, (2) probiotic reinforcement through genome editing technologies and (3) using self-targeting CRISPR systems as novel antimicrobials. The consecution of these objectives will lead to develop next generation probiotics to improve human health through immune modulation and vaccine delivery using beneficial bacteria, even to develop new antimicrobials based on CRISPR selective targeting of specific pathogens.
About the Speaker:
Dr. Claudio Hidalgo is originally from the northwest region of Spain, from a small region called Asturias. He earned his PhD in Microbiology and genetics (as well as BS Biology, MS Food Biotechnology), studying the health promoting effect of probiotics in general, and bifidobacteria in particular, and their interaction with human host to promote human health.
Lunch will be served!