Protein Function
Pathways
BioCarta Pathways
http://www.biocarta.com/genes/index.asp
Displays
online maps of pathways, primarily in humans, but information from some other
organisms. Molecular and cellular pathways are grouped by type, some examples
are apoptosis, cell cycle, signaling, expression, metabolism, and neuroscience.
Pathway diagrams are hyperlinked to records for over 120,000 genes. A gene
record includes links to multiple resources such nucleic acid and protein sequences,
disease information, and citations in PubMed.
MetaCyc
http://metacyc.org/index.shtml
The MetaCyc is a curated database containing non-redundant , experimentally
elucidated more than 500 metabolic pathways. Most of these pathways are for
plants and microorganisms, although more than 240 organisms are represented.
The database also includes almost 5,000 enzymatic reactions, and data about
enzymes and reactants. MetaCyc links to other biological databases containing
protein and nucleic acid sequence data, bibliographic data, and protein structures.
Pathguide: a Pathway Resource List
http://pathguide.org
A hyperlinked collection
of information about almost 200 published online databases. Pathway listings
are divided into 8 categories based on information type, e.g., metabolic, signaling,
protein-protein interaction, gene regulation/transcription factors, and more.
Additional information on coverage and features for each database is included.
Pathway Database (KEGG)
http://www.genome.jp/kegg/pathway.html
The
KEGG pathway database is one of four main integrated databases. (The other KEGG
databases cover genes, ligands, and ontologies.) The pathway database includes
manually drawn pathways covering a variety of biological processes such as metabolism,
signal transduction, genetic regulation, and human diseases. Pathway maps are
based on extensive reviews of the published literature.
Reactome: a curated knowledgebase of biological processes
http://pathema.tigr.org/cgi-bin/reactome/frontpage?DB=reactome
A curated database
of pathway information primarily focused on human reactions, covering biological
pathways ranging from the basic metabolic processes to higher-level processes
such as apoptosis. It also includes some reactions for rat, mouse, fugu fish,
and zebrafish. Includes links to UniProt and literature citations.
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