proteins: sequence, structure, and Function data
sequence | structure | families
and domains | function
iProClass--"one stop shopping for protein related information"
http://pir.georgetown.edu/iproclass/
This database integrates many types of
information about proteins from a multitude of online resources. For example,
it includes information about Structure (PDB, MMDB, others), Family (InterPro,
Pfam, others), Gene/Genome (GenBank, TIGR, and others), Function/Pathway (Kegg,
BioCarta, etc.) and several other types of data. iProClass includes links to
over 90 biological databases. iProClass is one of the family of PIR resources.
Major protein sequence data sources. Protein sequence databases are quite
often integrated with other types of organism information, such as genome
and nucleotide sequences and functional annotations related to structure,
function, and regulation.
Structure sources are of two main types. First are sites that include only
experimentally derived protein structures. Second are sites that attempt
to predict or model stucture from the amino acid sequence.
Most proteins can be grouped into families based on sequence similarities.
Proteins or protein domains in the same family generally share
functional attributes and are derived from a common ancestor. Within families
some regions have been better conserved than others during evolution. Such
regions are often important for protein function and/or structure.
By analyzing the properties of groups of similar sequences, it is possible
to derive a signature for a protein family or domain, which distinguishes
its members from all other unrelated proteins. (adapted from the ProSite
website)
Function Resources include actual and predicted protein function information
based on sequence or experimental data. One type of function related resources
is the construction of biological pathways (e.g., metabolism, signaling,
etc.). Other databases cover groups of proteins with similar functions, e.g.
G-proteins, enzymes, transcription factors, protein kinases, etc.
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